Catherine Rusoff
At least two human cases of new “double mutant” strains of H1N1 flu have been detected in U.S. patients, the Centers for Disease Control and Prevention said Wednesday, with genetic changes that could reduce the vaccine’s effectiveness. main antiviral against flu that hospitals rely on.
An analysis of the new H1N1 flu virus with these two worrisome mutations – which scientists call I223V and S247N, describing changes to the virus’s key surface proteins – was Published this week in the agency’s Emerging Infectious Diseases journal.
The following is a report from Hong Kong scientists who first tested for the mutations. Your laboratory experiments, published in Marchfound that the two mutations appeared to increase H1N1’s resistance to the flu treatment oseltamivir, commonly sold under the brand name Tamiflu by drugmaker Roche.
It’s unclear to what extent the mutations could reduce oseltamivir’s real-world effectiveness. A CDC spokesperson could not immediately comment on the new report.
Cases on several continents
Despite the “rapid spread of double mutations to countries on different continents,” the CDC report on the new double mutant flu strains concluded that the mutations still appear to be rare for now.
Since the mutations first appeared in a case sampled in the Canadian province of British Columbia in May 2023, a total of 101 sequences have been submitted to the GISAID global virus database from Africa, Asia, Europe, North America and Oceania. . These represent less than 1% of influenza virus sequences during that period.
The two U.S. cases were detected by laboratories at the Connecticut Department of Health and the University of Michigan last fall and winter.
“However, these data may not necessarily represent the true proportion of what was in circulation due to differences in surveillance and sequencing strategies in each country,” the authors said.
The most commonly prescribed antiviral
The CDC has long following closely potential mutations in the flu virus that could lead to resistance to oseltamivir.
Oseltamivir is the most commonly prescribed treatment for the flu, the CDC says. A published study last year found that the drug represented 99.8% of flu antivirals prescribed for children.
The C.D.C. insta Doctors should administer flu antivirals as quickly as possible to all flu patients who are hospitalized or at risk for severe illness. Doctors have also turned to oseltamivir to treat humans infected with the ongoing disease. H5N1 bird flu outbreak on dairy farms this year.
This is not the first time that health authorities have monitored the emergence of a potential threat to the effectiveness of flu treatments.
Before being wiped off the map by a competing strain of H1N1 behind the swine flu pandemic that swept the world in 2009, health authorities from Europe to Japan reported seeing outbreaks of an oseltamivir-resistant H1N1 strain in 2007 and 2008.
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